ГоловнаArchive of numbers2023Volume 31, issue 4(117)Clinical and phenomenological correlates of neuropsychiatric symptoms of vascular dementia
Title of the article Clinical and phenomenological correlates of neuropsychiatric symptoms of vascular dementia
Authors Dzis Myroslava
Rakhman Lyudmyla
In the section DIAGNOSTICS AND THERAPY OF MENTAL AND NARCOLOGICAL DISORDERS
Year 2023 Issue Volume 31, issue 4(117) Pages 49-55
Type of article Scientific article Index UDK 616.899.3:616.89-008.454]-036 Index BBK -
Abstract DOI: https://doi.org/10.36927/2079-0325-V31-is4-2023-7

 Taking into account the relevance of the diseases of old age and the consequences of cardiovascular diseases, which are increasing every year, we conducted a study of neuropsychiatric symptoms (NPS) of vascular dementia (VD) and the correlation of these symptoms both within one etiological group of dementia (VD) and in comparison with others groups (neurodegenerative disorders, NDD and mixed dementia, MD). With the statistical processing of data, a reliable relationship was established and the difference in the course of NPS in patients with VD was determined in relation to psychotic, affective and behavioral clusters of NPS. In the study of psychotic disorders, the highest frequency of delusions of poisoning is found in patients with VD. The study of affective disorders gave an understanding of higher frequency in combination of different manifestations of affective NPS within this cluster (in particular, apathy and anxiety in one patient) and with other clusters (for example, irritability and movement disorders or depression or anxiety and delusional syndrome) in patients with VD than among other etiological groups. Behavioral disorders in patients with VD were characterized by the following differences: wandering in the middle of the night is more common in patients with VD; the use of non-edible products is not as common in VD as in NDD. The study of neuropsychiatric symptoms in patients with vascular dementia makes it possible to better understand the peculiarities of the course of the pathology, evaluate the possibilities of implementing effective management of these symptoms, and predict their complications to ensure proper adaptation of the medical system, the patient and his caregivers to the challenges that arise when the diagnosis of vascular dementia is established.
Key words vascular dementia, psychotic symptoms, affective symptoms, behavioral symptoms, clinical features
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Bibliography 1. World Health Organization. Dementia. 2023. https://www. who.int/news-room/fact-sheets/detail/dementia.
2. Gao, S., Wang, Y., Ma, T., Zhang, J. (2023). The Late Stage of Abnormal Aging: Dementia. In: Zhang, Z. (eds) Cognitive Aging and Brain Health. Advances in Experimental Medicine and Biology, vol 1419. Springer, Singapore. https://doi.org/10.1007/978- 981-99-1627-6_12.
3. Schwertner E, Pereira JB, Xu H, Secnik J, Winblad B, Eriksdotter M, Nägga K, Religa D. Behavioral and Psychological Symptoms of Dementia in Different Dementia Disorders: A Large-Scale Study of 10,000 Individuals. J Alzheimers Dis. 2022;87(3):1307-1318. doi: 10.3233/JAD-215198. PMID: 35491774; PMCID: PMC9198804.
4. Okabe K, Nagata T, Shinagawa S, Inamura K, Tagai K, Nukariya K, Shigeta M. Effects of neuropsychiatric symptoms of dementia on reductions in activities of daily living in patients with Alzheimer’s disease. Geriatr Gerontol Int. 2020 Jun;20(6):584- 588. doi: 10.1111/ggi.13918. Epub 2020 Mar 31. PMID: 32232948.
5. García-Martín V, de Hoyos-Alonso MC, Ariza-Cardiel G, Delgado-Puebla R, García-Domingo P, Hernández-Melo E, de Haro-de Torres JL, Del Cura-González I. Neuropsychiatric symptoms and subsyndromes in patients with different stages of dementia in primary care follow-up (NeDEM project): a crosssectional study. BMC Geriatr. 2022 Jan 22;22(1):71. doi: 10.1186/ s12877-022-02762-9. PMID: 35065615; PMCID: PMC8783993.
6. Brandão T, Brites R, Hipólito J, Nunes O, Tomé Pires C. Emotion Regulation in Dementia Caregiving: The Role of Neuropsychiatric Symptoms and Attachment Orientation. Journal of Geriatric Psychiatry and Neurology. 2023;0(0). doi: 10.1177/08919887231195228.
7. Radue R, Walaszek A, Asthana S. Neuropsychiatric symptoms in dementia. Handb Clin Neurol. 2019;167:437-454. doi: 10.1016/B978-0-12-804766-8.00024-8. PMID: 31753148.
8. Art Walaszek. Behavioral and Psychological Symptoms of Dementia. Washington, DC; American Psychiatric Association Publishing; 2020; ISBN 978-1-61537-168-6; pp 269.
9. Majer R, Simon V, Csiba L, Kardos L, Frecska E, Hortobágyi T. Behavioural and Psychological Symptoms in Neurocognitive Disorders: Specific Patterns in Dementia Subtypes. Open Med (Wars). 2019 Apr 4;14:307-316. doi: 10.1515/med-2019-0028. PMID: 30997394; PMCID: PMC6463819.
10. Cognat E, Sabia S, Fayel A, Lilamand M, Handels R, Fascendini S, Bergh S, Frisoni GB, Fabbo A, Tsolaki M, Frölich L, Peters O, Merlo P, Ciccone A, Mecocci P, Dumurgier J, Defanti CA, Hugon J, Paquet C. BPSD Patterns in Patients With Severe Neuropsychiatric Disturbances: Insight From the RECAGE Study. Am J Geriatr Psychiatry. 2023 Aug;31(8):633-639. doi: 10.1016/j. jagp.2023.03.014. Epub 2023 Apr 23. PMID: 37183097.
11. Zlobin O. O. Stali kompleksy neiropsykhiatrychnoi symptomatyky, prytamanni khvorym z sudynnoiu dementsiieiu z riznoiu lokalizatsiieiu vohnyshch urazhennia holovnoho mozku [Stable complexes of neuropsychiatric symptoms in patients with vascular dementia with different localization of brain pathological focuses]. Ukrainskyi visnyk psykhonevrolohii [Ukrainian Bulletin of Psychoneurology]. 2020. T. 28, vyp. 3 (104). S. 44—50. DOI: https://doi. org/10.36927/2079-0325-V28-is3-2020-7. (In Ukrainian).
12. Savulich G, O’Brien JT, Sahakian BJ. Are neuropsychiatric symptoms modifiable risk factors for cognitive decline in Alzheimer’s disease and vascular dementia? Br J Psychiatry. 2020 Jan;216(1):1-3. doi: 10.1192/bjp.2019.98. PMID: 31036096.
13. Cummings J. The Role of Neuropsychiatric Symptoms in Research Diagnostic Criteria for Neurodegenerative Diseases. Am J Geriatr Psychiatry. 2021 Apr;29(4):375-383. doi: 10.1016/j. jagp.2020.07.011. Epub 2020 Jul 27. PMID: 32819825; PMCID: PMC7855689.
14. Mar J, Gorostiza A, Arrospide A, Larrañaga I, Alberdi A, Cernuda C, Iruin Á, Tainta M, Mar-Barrutia L, Ibarrondo O. Estimation of the epidemiology of dementia and associated neuropsychiatric symptoms by applying machine learning to real-world data. Rev Psiquiatr Salud Ment (Engl Ed). 2021 Mar 25:S1888-9891(21)00032-X. English, Spanish. doi: 10.1016/j. rpsm.2021.03.001. PMID: 33774222.
15. Bergh, S., & Selbæk, G. (2012). The prevalence and the course of neuropsychiatric symptoms in patients with dementia. Norsk Epidemiologi, 22(2). https://doi.org/10.5324/ nje.v22i2.1570.
16. Anor CJ, O’Connor S, Saund A, Tang-Wai DF, Keren R, Tartaglia MC. Neuropsychiatric Symptoms in Alzheimer Disease, Vascular Dementia, and Mixed Dementia. Neurodegener Dis. 2017; 17(4-5):127-134. doi: 10.1159/000455127. Epub 2017 Mar 1. PMID: 28245482.
17. Siqueira-Neto JI, Pontes-Neto OM, do Vale FAC, Dos Santos JV, Sales PMG, Dos Santos JV, Santos AC. Neuropsychiatric Symptoms (NPS) in patients with pure Vascular Dementia (VaD) and Mixed Dementia (MD) from a memory outpatient clinic in southeast Brazil. Dement Neuropsychol. 2013 Jul- Sep;7(3):263-268. doi: 10.1590/S1980-57642013DN70300006. PMID: 29213849; PMCID: PMC5619197.
18. Bandyopadhyay TK, Biswas A, Roy A, Guin DS, Gangopadhyay G, Sarkhel S, Ghoshal MK, Senapati AK. Neuropsychiatric profiles in patients with Alzheimer’s disease and vascular dementia. Ann Indian Acad Neurol. 2014 Jul;17(3):325-30. doi: 10.4103/0972-2327.138520. PMID: 25221405; PMCID: PMC4162022.
19. Tiel C, Sudo FK, Calmon AB. Neuropsychiatric symptoms and executive function impairments in Alzheimer’s disease and vascular dementia: The role of subcortical circuits. Dement Neuropsychol. 2019 Jul-Sep;13(3):293-298. doi: 10.1590/1980- 57642018dn13-030005. PMID: 31555401; PMCID: PMC6753905.
20. Delfino LL, Komatsu RS, Komatsu C, Neri AL, Cachioni M. Neuropsychiatric symptoms associated with family caregiver burden and depression. Dement Neuropsychol. 2021 Jan-Mar; 15(1):128-135. doi: 10.1590/1980-57642021dn15-010014. PMID: 33907606; PMCID: PMC8049583. 21. Regier NG, Hodgson NA, Gitlin LN. Neuropsychiatric symptom profiles of community-dwelling persons living with dementia: Factor structures revisited. Int J Geriatr Psychiatry. 2020 Sep;35(9):1009-1020. doi: 10.1002/gps.5323. Epub 2020 May 26. PMID: 32363605; PMCID: PMC8942615.
22. García-Martín V, de Hoyos-Alonso MC, Ariza-Cardiel G, Delgado-Puebla R, García-Domingo P, Hernández-Melo E, de Haro-de Torres JL, Del Cura-González I. Neuropsychiatric symptoms and subsyndromes in patients with different stages of dementia in primary care follow-up (NeDEM project): a crosssectional study. BMC Geriatr. 2022 Jan 22;22(1):71. doi: 10.1186/ s12877-022-02762-9. PMID: 35065615; PMCID: PMC8783993.