ГоловнаArchive of numbers2022Volume 30, issue 3 (112)Clinical and immunogenetic characteristics of healthy children born to multiple sclerosis patients
Title of the article Clinical and immunogenetic characteristics of healthy children born to multiple sclerosis patients
Authors Negreba Tetiana
Voloshyna Natalia
PogulyaevaTetiana
Chernenko Maksym
Vasylovskyi Vitalii
Voloshyn-Gaponov Ivan
In the section DIAGNOSTICS AND THERAPY OF NEUROLOGICAL, MENTAL AND NARCOLOGICAL DISORDERS
Year 2022 Issue Volume 30, issue 3 (112) Pages 120-126
Type of article Scientific article Index UDK Index BBK -
Abstract DOI: https://doi.org/10.36927/2079-0325-V30-is3-2022-94

 Purpose. To identify reliable predictor markers that indicate the possibility the development of a hereditary predisposition to MS based on the study of anamnestic, clinical, immunogenetic and neuroimaging features in practically healthy adult children born to parents with a sporadic form of this disease. Two groups of persons were examined: Primary group (practically healthy persons, born from sick parents) — 54 persons (27 men and 27 women) with an average age of 19.7 ± 2.0; observational group (persons born from healthy parents) — 20 persons (8 men and 12 women), with an average age of 20.5 ± 2.0). During the research the following points were studied: features of pregnancy and childbirth before the onset and against the background of MS in women who gave birth to healthy children; previous diseases (according to anamnesis), neurological status; peculiarities of immune status; prevalence of minor allele G (haplotype AG) in heterozygous individuals and prevalence major allele A (haplotype AA) in homozygous individuals; results of a neuroimaging study (MRI). In the primary group, the majority of women before the onset of MS (68.5 ± 6.3 %) had healthy children through physiological childbirth (83.4 ± 5.1) %. Against the background of the disease neither relapses of MS nor other complications were detected in pregnant women. Diseases suffered by persons living with MS in their family anamnesis from the parents included frequent bacterial-viral infections (chicken pox, ARVI, chronic ENT pathology — and bronchopulmonary pathology), which were able to start and maintain autoimmune reactions as a result of hypersensibilization developed. According to immunological studies, some of the persons examined demonstrated signs of immune imbalance (deficiency of immunoregulatory cells CD4, CD8, liquid lymphocytosis, decrease in natural killer cells, and increase in lymphocytotoxic autoantibodies) which indicated the presence of an inflammatory process with an autoimmune component. Status studies revealed minimal neurological symptoms in a small number of individuals (those symptoms were not pathognomonic for MS and did not significantly affect quality of life. According to the MRI data, no “dormant” foci of demyelination were detected which indicates absence of a subclinical course of MS in the examined persons. According to data of genetic studies, a reliable predominance of the AA haplotype over the AG haplotype was revealed, which is associated with the development of MS. Thus, the complex analysis of the received data gave an opportunity to distinguish “conditional” risk factors (high infectious index due to frequent bacterial-viral infections and, signs of immune imbalance) and anti-risk fac- tors (absence of neurological symptoms, pathogenic for MS, absence of “dormant” foci of demyelination, according to MRI data, reliable prevalence of AA haplotype over the AG haplotype) which, taking into account the hereditary predisposition to MS, can contribute or hinder further possible development of the demyeli nating process.
Key words multiple sclerosis, sporadic form, hereditary predisposition, healthy children
Access to full text version of the article pdf download
Bibliography 1. Favorova O. O., Bojko A. N., Kulakova O. G. Rasseyanny’j skleroz kak poligennoe zabolevanie: sovremennoe sostoyanie. Genetika. 2010. T. 46. No. 3. S. 302-313.
2. Bojko A. N., Gusev E. I. Dostizheniya v izuchenii problem rasseyannogo skleroza (obzor). Doktor.Ru. Nevrologiya, psixiatriya. 2012. No. 73 (5). S. 9-15.
3. Korobko D. S.,. Malkova N. A. i dr. Vliyanie geneticheskix faktorov na fenotipicheskuyu e’kspressiyu rasseyannogo skleroza. Zhurnal nevrologii i psixiatrii im. S. S. Korsakova. 2013. No. 2. S. 10-16.
4. Ramagopalan S., Sadovnick A. Genetics and epidemiology of multiple sclerosis. Primer on multiple sclerosis. 2011. P. 15-29.
5. Al Jumah M, Kojan S, Al Khathaami A, Al Abdulkaream I, Al Blawi M, Jawhary A. Familial multiple sclerosis: does con- sanguinity have a role? Mult Scler. 2011 Apr;17(4):487-9. doi: 10.1177/1352458510390406.
6. Balcerac A., Louapre C. Genetics and familial distribution of multiple sclerosis: A review. Revue Neurologique. 2022. Vol. 178, Issue 6. P. 512-520. https://doi.org/10.1016/j.neurol.2021.11.009.
7. Voloshyna N. P., Nehreba T. V., Vasilovskij V. V. y dr. Sravnitel'naya klini ches kaya xarakteristika razny'x tipov techeniya semejny'x i sporadi cheskix form rasseyannogo skleroza. Ukrain- skyi visnyk psykhonevrolohii. 2018. T. 26, vyp. 1 (94). S. 10-19.
8. McElroy JP, Oksenberg JR. Multiple sclerosis genetics. Current Topics in Microbiology and Immunology. 2008; 318: 45-72. doi: 10.1007/978-3-540-73677-6_3.
9. Olsson T, Barcellos LF, Alfredsson L. Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis. Nat Rev Neurol. 2017 Jan;13(1):25-36. doi: 10.1038/ nrneurol.2016.187. 10. Vasylovskyi V. V. Prohrediientni typy perebihu rozsiiano- ho sklerozu: kliniko-patohenetychna kharakterystyka perebihu, prohnoz ta novi pidkhody do stratehii likuvannia : dys. … d-a med. nauk. Kharkiv, 2019. 467 s.
11. Pogulyaeva T. M. Kliniko-imunohenetychna kharakterystyka khvorykh z sporadychnoiu ta simeinoiu formamy rozsiianoho sklerozu: dyferentsialna diahnostyka, prohnoz, vplyv vahitnosti ta polohiv pry dvokh formakh rozsiianoho sklerozu : dys. kan- dydata med. nauk. Kharkiv, 2020. 188 s. 12. Nehreba T. V. Klinichna diahnostyka riznykh typiv perebihu rozsiianoho sklerozu. Zbirka anket : Avtorske pravo na naukovyi tvir No. 8675 vid 31.10.2003.
13. Voloshina N. P., Vasilovskij V. V., Chernenko M. E. Vliyanie infekcionnogo faktora na sostoyanie gematoe’ncefalicheskogo bar’era u bol’ny’x rasseyanny’m sklerozom. Ukrainskyi visnyk psykhonevrolohii. 2013. T. 21, vyp. 1 (74). S. 5-7.
14. Koliada T. I., Voloshina N. P., Nehreba T. V. Porivnialna kharakterystyka imunnoho statusu pry riznykh typakh perebihu rozsiianoho sklerozu. Ukrainskyi visnyk psykhonevrolohii. 2004. T. 12, vyp. 2 (39). S. 88-94.
15. Gandhi R, Laroni A, Weiner HL. Role of the innate immune system in the pathogenesis of multiple sclerosis. J Neuroimmunol. 2010 Apr 15;221(1-2):7-14. doi: 10.1016/j. jneuroim.2009.10.015.
16. Vasilovskij V. V., Voloshina N. P., Negreba T. V., Levchen- ko I. L. Sravnitel’naya strukturno-funkcional’naya xarakteristika immunnogo disbalansa u licz raznogo pola pri recidiviruyush- hem i progredientny’x tipax techeniya rasseyannogo skleroza. Ukrainskyi visnyk psykhonevrolohii. 2014. T. 22, vyp. 1 (78). S. 28-36.
17. Wattjes MP, Ciccarelli O, Reich DS, Banwell B, de Stefa- no N, Enzinger C, Fazekas F, Filippi M, Frederiksen J, Gasperini C, Hacohen Y, Kappos L, Li DKB, Mankad K, Montalban X, New- some SD, Oh J, Palace J, Rocca MA, Sastre-Garriga J, Tintoré M, Traboulsee A, Vrenken H, Yousry T, Barkhof F, Rovira À; Magne- tic Resonance Imaging in Multiple Sclerosis study group; Consortium of Multiple Sclerosis Centres; North American Imaging in Multiple Sclerosis Cooperative MRI guidelines working group. 2021 MAGNIMS-CMSC-NAIMS consensus re- commendations on the use of MRI in patients with multiple sclerosis. Lancet Neurol. 2021 Aug;20(8):653-670. doi: 10.1016/ S1474-4422(21)00095-8.