ГоловнаArchive of numbers2021Volume 29, issue 2 (107)Peculiarities of neuroregulatory mechanisms of adaptation under alcohol dependence (experimental study)
Title of the article Peculiarities of neuroregulatory mechanisms of adaptation under alcohol dependence (experimental study)
Authors Berchenko Olga
Titkova Anna
Shlyakhova Anna
Veselovska Olena
Prikhodko Olena
Year 2021 Issue Volume 29, issue 2 (107) Pages 36-40
Type of article Scientific article Index UDK 612.820:616-092.9 Index BBK -
Abstract DOI: https://doi.org/10.36927/2079-0325-V29-is2-2021-6 Neurophysiological and biochemical markers of alcohol dependence were identified in a study conducted in laboratory rats at the systemic and molecular levels. It has been shown that long-term alcohol consumption is accompanied by an increase in dopamine levels in the ventral tegmental area and a decrease in GABA and BDNF levels in the hippocampus and serum and leads to attenuation of neocortex control of the limbic emotional-motivational system of the brain. Disturbance of the mechanisms of structural and functional organization of wake-sleep processes and regulation of emotional reactions, which is reflected in the suppression of slow-wave sleep, reduction of paradoxical sleep, inhibition of positive emotional centers, the development of anxiety and depression have been determined. Key words: alcohol dependence, sleep-wake, anxiety, depression, catecholamines, GABA, BDNF
Key words alcohol dependence, sleep-wake, anxiety, depression, catecholamines, GABA, BDNF
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