ГоловнаArchive of numbers2021Volume 29, issue 2 (107)Hereditage and socially stress load in the pathogenesis of recurrent depressive disorders
Title of the article Hereditage and socially stress load in the pathogenesis of recurrent depressive disorders
Authors Maruta Natalia
Kolyadko Svitlana
Fedchenko Viktoriya
Cheredniakova Olena
In the section DIAGNOSTICS AND THERAPY OF MENTAL AND NARCOLOGICAL DISORDERS
Year 2021 Issue Volume 29, issue 2 (107) Pages 47-51
Type of article Scientific article Index UDK 616.895.4-02-056.7:316.472 Index BBK -
Abstract DOI: https://doi.org/10.36927/2079-0325-V29-is2-2021-8 The paper presents the results of a comprehensive clinical-genealogical, clinical-anamnestic and psychodiagnostic examination of patients with recurrent depression. The features, structure and role of heredity factors and social stress factors in the formation of recurrent depression have been investigated. The presence of a significant family accumulation of depressive disorders in the pedigrees was revealed in patients with recurrent depressive disorders, predominantly in the mother’s line. It was found that an important provoking factor in the development of depressive disorders is the presence of factors of mental traumatization, mainly social and psychological. It has been proved that a significant role in the pathogenesis of depression belongs not to the number of stressful events, but to the level of their stressfulness. The results obtained show that the formation of depressive disorders is determined by the presence of a combined effect of clinical and genealogical, social and environmental and socio-psychological factors.
Key words recurrent depressive disorder, hereditary burden, factors of mental traumatization, level of stress load
Access to full text version of the article pdf download
Bibliography 1. World Health Organization. Depression and other common mental disorders: Global health estimates. 2017. URL: http://www.euro.who.int/document /mnh/edoc17.pdf. 2. Maruta, N. A. Diagnostika i terapiya unipolyarnyih depressiy v sovremennyih usloviyah: mifyi i realnost // Нейро News. 2013. № 2 (47). 3. Gene × environment determinants of stress- and anxiety-related disorders / S. Sharma, A. Powers, B. Bradley & K. J. Ressler // Annual Review of Psychology. 2016. Vol. 67. Р. 239—261. DOI: https://doi.org/10.1146/an¬nurev-psych-122414-033408. 4. Significance of risk polymorphisms for depression depends on stress exposure/ X. Gonda, G. Hullam, P. Antal [et al.] // Scientific Reports. 2018. Vol. 8. 3946 (2018). DOI: https://doi.org/10.1038/s41598-018-22221-z. 5. Polygenic risk, stressful life events and depressive symp¬toms in older adults: a polygenic score analysis / K. L. Musliner, F. Seifuddin, J. A. Judy [et al.] // Psychological Medicine. 2015. No. 45. 1709—1720. DOI: 10.1017/S0033291714002839. 6. Brain galanin system genes interact with life stresses in depression-related phenotypes / G. Juhasz, G. Hullam, N. Eszlari [et al.] // Proceedings of the National Academy of Sciences of the United States of America. 2014. Vol. 111. Р. 1666—1673. DOI: https://doi.org/10.1073/pnas.1403649111. 7. Flint J., Kendler K. S. The Genetics of Major Depression // Neuron. 2014. Vol. 81. P. 484—503. DOI: 10.1016/j.neu¬ron.2014.01.027. 8. Geneticheskie osnovyi predraspolozhennosti k depres¬sivnyim rasstroystvam / Yu. D. Davyidova, R. F. Enikeeva, A. V. Kazantseva [i dr.] // Vavilovskiy zhurnal genetiki i selektsii. 2019. № 23(4). S. 465—472. DOI: https://doi.org/10.18699/VJ19.515. 9. Kasyanov E. D., Mazo G. E., Kibitov A. O. V pois¬kah «nasledstvennyih» form depressii: klinicheskie, geneticheskie i biologicheskie podhodyi // Sotsialnaya i klinicheskaya psihiatriya. 2018. T. 28. №1. S. 74—82. URL: https://cyberleninka.ru/article/n/v-poiskah-nasledstven¬nyh-form-depressii-klinicheskie-geneticheskie-i-biologiches¬kie-podhody. 10. Karpovich, T. N. Psihologicheskaya diagnostika sotsialnogo intellekta lichnosti. Mozyir : Sodeystvie, 2007. S. 27—29.